Ranking 9 Top with 12M Views (Over 4,500 Comments Analyzed)
Best YouTube Video about Ozempic Ranking 9 Top Videos with 12M Views (Over 4,500 Comments Analyzed)
Why Ozempic Matters, Why Analyze Comments
The emergence and widespread popularity of Ozempic (semaglutide) have ignited a global debate surrounding weight loss, chronic disease management, and media ethics. Originally FDA-approved for treating Type 2 diabetes to control blood sugar and decrease the likelihood of major cardiovascular events, Ozempic has been widely adopted for weight reduction, often through off-label use.
This “Ozempic craze,” fueled partly by celebrity promotion and social media trends, presents a challenging landscape for individuals seeking reliable medical advice. This article assesses which video offers the most valuable guidance by analyzing the engagement patterns and content of thousands of viewer comments across five major YouTube discussions. Analyzing viewer comments reveals not only the effectiveness of communication but also the genuine confusion, anxiety, and information gaps experienced by the public.
Truth Behind Ozempic Weight Loss Trend ft. My Wife
Doctor Gary Linkov
Highest positive sentiment; strong ethical and body-positivity framework.
#2
Johann Hari: They’re Lying To You About The Side Effects Of Ozempic!
The Diary Of A CEO
Most balanced and humane discussion of behavioral and societal context.
#3
The Many Lies About The Ozempic Weight Loss Craze
Doctor Mike
Strong focus on correcting misinformation and protecting diabetic access.
#4
What Ozempic & Weight Loss Drugs Really Do to the Body
Institute of Human Anatomy
Exceptional clarity and scientific breakdown of mechanisms.
#5
Dr Jason Fung’s BRUTALLY Honest Opinion On OZEMPIC!
The Diary Of A CEO Clips
Strong advocacy for fasting and hormone-based lifestyle alternatives.
5 Deep Dives
1. Doctor Gary Linkov — “Truth Behind Ozempic Weight Loss Trend ft. My Wife” (V3)
Why #1: This video achieved the highest positive sentiment (53.20%) and the highest proportion of compliments (35.46% of sampled comments) among the core group. Viewers universally praised the clarity, professionalism, and the compassionate, ethical stance delivered by Dr. Liz Grand. The combination of a plastic surgeon’s perspective on "Ozempic face" and an internal medicine specialist’s deep dive into metabolic health offered a uniquely comprehensive view.
Audience Pulse: Audiences were impressed, grateful, and particularly loved the synergy between Dr. Linkov and his wife, Dr. Grand, frequently requesting more content from the "beautiful brainiac couple". There was strong emotional resonance with the messaging about societal body standards and pharmaceutical influence.
Actionable Takeaways:The critical need for self-love and body acceptance alongside treatment; prioritizing the drug for patients with medical needs (T2DM, obesity); understanding that weight regain is likely upon cessation unless profound, lasting lifestyle changes are made.
Caveats: The main friction point was the reality of shortages and access, with diabetics complaining that cosmetic use by celebrities was preventing those in medical need from getting the drug.
2. Steven Bartlett — “Johann Hari: They’re Lying To You About The Side Effects Of Ozempic!” (V5)
Why #2: This extended interview was lauded for its balanced, humane, and deeply researched discussion. It moved beyond simple mechanisms to explore the psychological and sociological factors of obesity, addiction, and food noise. Viewers found it "fascinating," "enlightening," and a "fantastic and moving interview".
Audience Pulse: Highly engaged; viewers watched the entire multi-hour video and took notes. The key emotions were impression and gratitude, particularly for Hari's eloquent and relatable exploration of human struggle.
Actionable Takeaways: GLP-1s may help counter/lower other addictive behaviors (alcohol, drugs) by changing brain chemistry and suppressing cravings; the importance of therapy and mental health support for underlying emotional eating issues; and the necessity of pairing medication with strength training and high protein intake to mitigate muscle loss.
Caveats: Some friction arose regarding the perceived lack of specific scientific depth or statistical data on side effects, while others questioned the concept of the "set point".
3. Doctor Mike — “The Many Lies About The Ozempic Weight Loss Craze” (V1)
Why #3: Dr. Mike’s video provided an early, evidence-based antidote to misinformation, focusing on the ethical responsibility of prescribing and the logistical nightmares faced by patients. As a clinician, he emphasized that medication should never be a first line of defense.
Audience Pulse: The audience was highly engaged, with personal stories (41.45%) and complaints (24.89%) dominating the comment type breakdown. Viewers were frustrated and concerned about misinformation and shortages.
Actionable Takeaways: Prioritize lifestyle changes first, then medication if needed, using a risk-benefit analysis; the medication is NOT insulin; patients must receive a plan for nutrition (macros/micros) and resistance training to minimize GI side effects and muscle loss; and understanding the role of co-morbidities like PCOS, thyroid issues, and pre-diabetes.
Caveats: A significant number of complaints highlighted that the demand for cosmetic use was crippling the supply chain for T2DM patients.
4. Institute of Human Anatomy — “What Ozempic & Weight Loss Drugs Really Do to the Body” (V2)
Why #4: This video excelled in providing a clear, articulate, and scientifically rigorous explanation of the biological mechanisms of GLP-1 agonists. Viewers praised the hosts for their teaching quality and accessibility, often calling it the "best and most clear and concise explanation".
Audience Pulse: The video generated the highest percentage of personal stories (47.80%) among the sampled videos, suggesting strong resonance and relatability. Commenters appreciated the unbiased approach grounded in scientific facts.
Actionable Takeaways: Understanding that the drug is not magic; it primarily works through appetite suppression to facilitate eating less; recognition of the risk of muscle, bone, and mass loss alongside fat; and the importance of preparing for discontinuation by establishing exercise and diet habits.
Caveats: Some feedback focused on the context of the presentation (surrounded by anatomical cadavers) as subtly unsettling, while others criticized the high cost of the drug in the U.S. compared to countries like Japan or the U.K.
5. Steven Bartlett — “Dr Jason Fung’s BRUTALLY Honest Opinion On OZEMPIC!” (V4)
Why #5: Dr. Fung's perspective was highly valued for focusing heavily on root causes (hormones) and lifestyle alternatives (fasting/keto). Many credited him with reversing their Type 2 diabetes through his methods.
Audience Pulse: The audience showed immense respect for Dr. Fung's expertise, calling him a "ROCK STAR" and a hero. However, there was measurable friction due to sensationalist video titling ("BRUTALLY Honest") which many felt did not match the content, and technical critiques of the host's questioning.
Actionable Takeaways: Emphasis on alternatives: Intermittent and extended fasting, skipping unhealthy carbs, eating protein and fiber; the belief that obesity is largely a hormone-driven behavior rather than a lack of control; and the necessity of changing one's entire diet and exercise approach for life to avoid weight regain, regardless of medication use.
Caveats: Strong warnings surfaced about severe side effects like gastroparesis (stomach paralysis) and the irreversible nature of muscle loss (sarcopenia). The lack of discussion on emotional overeating was also flagged as a significant omission.
Practical Toolkit (What Viewers Can Apply Right Away)
Based on the highest-value feedback and consensus across all analyzed videos, viewers should prioritize the following practical steps, whether using GLP-1 medication or pursuing natural weight loss:
Prioritize Protein and Strength Training: To counteract muscle-mass loss often associated with rapid weight loss, consistently aim for high protein intake and integrate resistance training or weight lifting.
Focus on Nutrient Density: Since appetite is suppressed, every meal should be nutrient-dense; minimize ultra-processed foods and sugar.
Manage Gastrointestinal (GI) Effects: Eat slower and decrease portion sizes to manage common side effects like GI distress and fullness.
Adopt Long-Term Lifestyle Habits: Recognize weight management as lifelong; use medication only as a “bridge” to establish permanent habits.
Consult Experts: Work with healthcare providers and Registered Dietitians; request blood tests (Vitamin D3, kidney function, A1C).
The Questions Viewers Kept Asking
Theme
Common Questions
Long-Term Safety & Efficacy
What are the long-term effects, especially for non-diabetics? Do I have to take this medication forever? Why does weight come back when stopping? Is it safe for kidneys, liver, or heart?
Side Effects
What is the real risk of gastroparesis or bowel obstruction? Are mentions of eye damage, blindness, or thyroid-cancer risk accurate? What causes sulfur burps and severe gas?
Access & Cost
What is the true cost (~$1000 / month US) versus other countries? How can I navigate insurance, prior authorizations, and shortages?
Appropriate Use
Is it safe/effective for PCOS, pre-diabetes, insulin resistance, or hypothyroidism? Why Ozempic for weight loss when Wegovy is approved? Should teens take it?
Metabolic Mechanisms
Is Ozempic simply an “eat-less pill” or does it affect cravings or emotional eating?
Physical Composition
How to lose fat but keep lean muscle mass? Does it cause “Ozempic face”?
Feedback and Complaints
Supply Shortages and Ethical Use: Diabetics complained off-label cosmetic use caused shortages, calling it “heartbreaking”.
Media and Advertising: Viewers criticized celebrity glamorization during shortages as profit-driven.
Lack of Comprehensive Care: Doctors prescribed without teaching portion control, slow eating, or resistance training.
Systemic Issues: High U.S. cost and lack of insurance coverage for nutrition experts.
Explore the Complete Ozempic & GLP-1 Deep-Dive Series
Discover evidence-based insights from real patient stories and medical commentary — covering every key question about Ozempic and GLP-1 drugs: from stopping and weaning off, muscle preservation, and mood effects to cost, compounding, addiction, and ethical use in teens.
The video offering the most valuable, balanced, and ethically sound guidance is "Truth Behind Ozempic Weight Loss Trend ft. My Wife" (Doctor Gary Linkov).
This video uniquely integrates medical science with necessary cultural and ethical context. It earned the highest positive audience feedback through the clear, detailed, and compassionate explanations provided by Dr. Liz Grand. It effectively addressed:
Scientific Mechanism: Explained how Ozempic works beyond appetite suppression.
Ethical Priority: Prioritized access for medical cases (T2DM/obesity) over trend-driven cosmetic use.
Comprehensive Safety: Detailed side effects and weight-regain risk upon cessation.
Societal Impact: Challenged “fad” body-culture, promoting self-acceptance and health focus.
For alternatives, “Johann Hari: They’re Lying To You About The Side Effects Of Ozempic!” (The Diary Of A CEO) provides unmatched psychological and behavioral insight.
Audience Sentiment at a Glance
Video Title
Positive (%)
Neutral (%)
Negative (%)
Top Emotions
Doctor Gary Linkov (V3)
53.20
25.10
19.90
Grateful, Impressed, Curious
Dr. Mindy Pelz (V9)
55.77
27.58
16.65
Grateful, Impressed, Curious
Tucker Carlson (V6)
48.83
34.45
16.51
Frustrated, Concerned
Doctor Mike (V1)
46.50
31.27
21.93
Frustrated, Curious
Johann Hari (V5)
44.59
32.77
22.55
Impressed, Grateful
Dr. Jason Fung (V4)
42.15
33.37
23.94
Critical, Frustrated
IoHA (V2)
41.15
34.90
23.03
Impressed, Concerned
Dr. Mike (V8)
42.00
40.60
16.40
Concerned, Critical
Dr. Hyman / Moore / Means (V7)
47.24
32.10
20.26
Frustrated, Critical
Short Takeaway: The highest rates of positive sentiment correlated strongly with videos featuring female doctors (Dr. Liz Grand, Dr. Mindy Pelz, Dr. Tyna Moore) and discussions that paired scientific clarity with compassion and addressed body image concerns. Conversely, videos dealing explicitly with shortages or systemic flaws saw high levels of frustration and critical feedback.
Per-Video Snapshot
Video Title
Channel
Views (M)
Likes (K)
Comments (K)
Likes/Views (%)
Comments/Views (%)
The Many Lies About...
Doctor Mike
2.6
73
5.5
2.81%
0.21%
What Ozempic ... Really Do
IoHA
1.9
43
3.6
2.26%
0.19%
Truth Behind Ozempic...
Doctor Gary Linkov
3.2
70
5.4
2.19%
0.17%
Dr Jason Fung’s Opinion
DOAC Clips
2.0
47
3.3
2.35%
0.16%
Johann Hari ... Side Effects
The Diary Of A CEO
2.2
47
7.0
2.14%
0.32%
Methodology and Limitations
This analysis is based strictly on the content provided in the comment reports and excerpts for five central videos, supplemented by information from four additional related reports (snapshot Oct 2025). The analysis relies on Shono AI comment reports that classify viewer input by sentiment, emotion, and comment type. “Value” and ranking were determined by combining quantifiable metrics with qualitative assessments of highly engaged viewer feedback. Limitations include partial availability of view/like metrics and model-based sentiment interpretation.
FAQs (10 Items)
1. Is Ozempic simply an "eat-less pill" that relies solely on calorie reduction?
No. While it suppresses appetite and makes dieting easier, it is a GLP-1 receptor agonist that mimics a hormone regulating blood sugar and appetite. It slows gastric emptying and stimulates insulin secretion.
2. Do I need to make lifestyle changes even if I take Ozempic?
Yes. Experts consistently emphasize that Ozempic is a tool that must be used alongside a healthy diet, exercise, and lifestyle changes.
3. What are the most serious side effects people are concerned about?
Concerns focus on gastroparesis, nausea, vomiting, and pancreatitis; rare risks include thyroid cancer and retinopathy.
4. Will I regain all the weight if I stop taking the medication?
Yes — weight regain is very likely unless new, sustainable habits are formed.
5. How can I prevent muscle loss (sarcopenia) while losing weight on Ozempic?
Focus on resistance training and a high-protein diet to preserve lean mass.
6. Is Ozempic safe for people who are not diabetic?
It is prescribed off-label (e.g., for PCOS or pre-diabetes) but not FDA-approved for weight loss like Wegovy.
7. Is Ozempic the same as insulin?
No. Ozempic stimulates the pancreas to release insulin but is not insulin itself.
8. Why is there a shortage of Ozempic?
Driven by high off-label demand for cosmetic weight loss, reducing supply for diabetics.
9. What is the difference between Ozempic and Mounjaro (tirzepatide)?
Mounjaro is a dual-acting GIP and GLP-1 agonist, potentially with fewer side effects.
10. Why is the drug so much cheaper in other countries than in the U.S.?
Due to health-system pricing differences: U.S. ≈ $1000/month vs much lower in U.K./Japan.
